|GRE4Zn: Geometric REstriction for Zinc-binding|
As one of the most essential metals utilized by organisms, zinc is critical for structural, catalytic and regulatory functions of proteins. Zinc-binding proteins play an important role in a variety of biological processes such as transcription regulation, cell metabolism and apoptosis. Characterizing the precise zinc-binding sites is fundamental for dissecting the biological functions and molecular mechanisms of zinc-binding proteins. Since experimental identification of bona fide zinc-binding sites is time-consuming and labor-intensive, a number of computational algorithms were adopted for training on known data set .